Publications
* co-corresponding authors; # authors contributed equally to this work
2025
Yang X., Zhang X., Li W., Gharpure A., Hansel-Harris A., Tillack A.F., Wu C., Hsieh Y-Z., Sulpizio A., Dikiy S., Zhao X., Forli S., Lairson L., Ward A., Parker C.G., Hang H. “Microbiota-derived secondary bile acids promote STING activation and antitumor activity” 2025, bioRxiv preprint, doi.org/10.1101/2025.04.16.649255
Tang W., Black A.S., Moench R., Marzban K., Raygoza Garay J.A., Zheng J.J., Conway L.C., Pinto A.F.M., Parker C.G., Saghatelian A., Leman L.J., Ghadiri M.R. “Trifluoroacetate reduces plasma lipid levels and the development of atherosclerosis in mice”, 2025, bioRxiv preprint, doi.org/10.1101/2025.03.06.641713
Forrest, I., Conway, L. P., Jadhav M.A, Gathmann, C., Chiu, T. Y., Chaheine, C. M., Estrada, M., Shrestha A., Warder S. E., Vasudevan, A., McLoughlin, S. M, Parker, C. G. “Proteome-wide discovery of degradable proteins using bifunctional molecules”, 2025, bioRxiv preprint, doi.org/10.1101/2025.03.21.644652
Chaheine, C., Conway, L.C., Parker, C.G. “Fully-functionalized natural product probes to expand the chemical tractability of the human proteome", 2025, ChemRxiv preprint, doi.org/10.26434/chemrxiv-2025-hfmv4
Vazquez-Villa, H., Rueda-Zubiaurre, A., Fernandez, D., Foronda, R., Parker, C. G., Cravatt, B. F., Martin-Fontecha, M., & Ortega-Gutierrez, S. “Chemical probes for the identification of the molecular targets of honokiol,” 2025, Eur J Med Chem, 283, 117102
2024
Wozniak, J.M.#; Li, W.#; Parker, C.G. “Chemical proteomic mapping of reversible small molecule binding sites in native systems,” 2024, Trends Pharm Sci, 45, 969
Reeves, A.E.; Vilen, Z.V.; Fuentecilla, T.R.; Parker, C.G.; Huang, M. L. “Charting the dynamic trophoblast plasma membrane identifies LYN as a functional regulator of syncytialization,” 2024, ACS Chem Biol, 19, 2220
Chen, L-Y.#, Roy, S.J.S.#, Jadhav, A. M.; Wang, W.W.; Chen, P-H.; Bishop, T.; Erb, M.A.; Parker, C.G. “Functional investigations of p53 acetylation enabled by heterobifunctional molecules,” ACS Chem Biol, 2024, 19, 1918
O’Brien, J.G.K#; Conway, L.P.#; Ramaraj, P.K.; Jadhav, A.M.; Jin, J.; Dutra, J.K.; Evers, P.; Masoud, S.S.; Schupp, M.; Saridakis, I.; Chen, Y.; Maulide, N.; Pezacki, J.P.; am Ende, C.W.*; Parker, C.G.*; Fox, J.M.* “Mechanistic differences between linear vs spirocyclic dialkyldiazirines probes for photoaffinity labeling,” Chemical Science, 2024, 15, 15453.
Homan, R.A.; Lapek, J.D.; Woo, C.M.; Niessen, S.; Jones, L.H.; Parker, C.G. “Photoaffinity labelling with small molecules,” Nature Rev Methods Primers, 2024, 4, 30
Chiu, T-Y.#; Lazar, D.C.#; Wang, W.W.#; Li, W.; Jadhav, A.M.; Wozniak, J.M.; Gazaniga, N.; Theofilopoulous, A.N.; Teijaro, J.R.; Parker, C.G. “Chemoproteomic development of SLC15A4 inhibitors with anti-inflammatory activity”, Nature Chem Biol, 2024, 20, 1000
• bioRxiv preprint, 2022, doi.org/10.1101/2022.10.07.511216
• Highlighted in Nature Chem Biol News & Views and Nature Reviews Drug Discovery
Wozniak, J.M.#; Li, W.#; Governa, P.; Chen, L.Y.; Jadhav A. J.; Dongre, A.; Forli, S.; Parker, C.G. “Enhanced Mapping of Small Molecule Binding Sites in Cells,” Nature Chem Biol, 2024, 20, 823
2023
Wichroski, M.; Benci, J.; Liu, S.; Chupak, L.; Fang, J.; Cao, C.; Wang, C.; Russo, J.; Qiu, H.; Shan, Y.; Banas, D.; Poweles, R.; Locke, G.; Witt, A.; Stromko, C.; Qi, H.; Zheng, X.; Martin, S.; Ding, M.; Gentles, R.; Meanwell, N.; Velaparthi, U.; Olson, R.; Wee, S.; Tenney, D.; Parker, C.G.; Cravatt, B.F.; Lawrence, M.; Borzilleri, R.; Lees, E. “DGKa/z Inhibitors Combine With PD-1 Checkpoint Therapy To Induce Robust T Cell-Mediated Anti-Tumor Immunity,” Sci Trans Med, 2023, 15, eadh1892
Tang, J.#; Li, W.#; Chiu, T-Y.; Luo, Z.; Chong, C. T.; Wei, Q.; Martínez-Peña, F.; Gazaniga, N.; See, Y. Y.; Lairson, L. L.*; Parker, C.G.;* Baran, P. S.* “Synthesis of Portimines Reveals the Basis of their Anti-cancer Activity,” Nature, 2023, 622, 507
ChemRxiv preprint, 2023, doi.org/10.26434/chemrxiv-2023-w286t
Forrest, I.; Parker, C.G. “Proteome-Wide Fragment-Based Ligand and Target Discovery,” Isr J Chem, 2023, e202200098
Fernández Vega, V.; Yang, D.; Ortiz Jordán, L.; Ye, F.; Conway, L.; Chen, L.Y.; Shumate, J.; Baillargeona, P.; Scampavia, L.; Parker, C.G.; Shen, B.; Spicer, T.P. “Protocol for 3D screening of lung cancer spheroids using natural products,” SLAS Discovery, 2023, 28, 20
Chen, L-Y; Wang, W.W; Wozniak, J, Parker, C.G. “A Heterobifunctional Molecule System for Targeted Protein Acetylation in Cells,” Methods Enzymol, 2023, 681, 287
2022
Hassan, A.A.#; Wozniak, J.M.#; Jadhav, A.J.; Li, W.; Vilen, Z.; Parker, C.G.*; Huang, M.L.* “Chemoproteomic Identification of Human Milk Oligosaccharide Targets in Live Cells,” RSC Chemical Biology, 2022, 3, 1369 (Invited submission for chemical proteomics themed collection)
Homan, R.; Jadhav, A.; Conway, L.; Parker, C.G. “A Chemical Proteomic Map of Heme-Protein Interactions” J Am Chem Soc, 2022, 144, 15013
Rimann, I.; Gonzalez-Quintial, R.; Baccala, R.; Kiosses, W.B.; Teijaro, J.R.; Parker, C.G.; Li, X.; Beutler, B.; Kono, D.H.; Theofilopoulous, A.N. “The Solute Carrier SLC15A4 is Required for Optimal Trafficking of Nucleic Acid-Sensing TLRs and Ligands to Endolysosomes” Proc Natl Acad Sci, 2022, 119, e2200544119
2021
Wang, W.W.#; Chen, L-Y#; Wozniak, J.M.; Jadhav, A.M.; Anderson, H.; Malone, T.M.; Parker, C.G. “Targeted Protein Acetylation in Cells Using Heterobifunctional Molecules,” J Am Chem Soc, 2021, 143, 16700
bioRxiv preprint, 2021, doi.org/10.1101/2021.07.27.454011
Vilen, Z.; Joeh, E.; Critcher, M.; Parker, C.G.; Huang, M.L. “Proximity tagging identifies the glycan-mediated glycoprotein interactors of galectin-1 in muscle stem cells” ACS Chem Biol, 2021, 16, 1994
Conway, L. P.#; Jadhav, A.M.#; Homan, R. A.#; Li, W.; Rubiano, J.S.; Hawkins, R.; Lawrence, R.M.; Parker, C.G. “Evaluation of Fully-Functionalized Diazirine Tags for Chemical Proteomic Applications”, Chemical Science, 2021, 12, 7839
Hong, S.H. #; Yoo, D.Y. #; Conway, L.; Richards-Cork K.C.; Parker, C.G.; Arora, P.S. “A Sos Proteomimetic as a Pan-Ras Inhibitor” Proc Natl Acad Sci, 2021, 118, e2101027118
Joeh, E.; Reeves, A.E.; Parker, C.G.; Huang, M.L. “Mapping Glycan to Glycan Binding Protein (GBP) Interactions by Live Cell Proximity Tagging” Curr Prot in Chem Biol, 2021, 117, 27329
Conway, L. C.; Li, W.; Parker, C.G. “Chemoproteomic-Enabled Phenotypic Screening” Cell Chemical Biology; 2021, 28, 371
2020
Suresh, B.M.; Li, W.; Zhang, P.; Wang, K.W.; Yildirim, I.; Parker, C.G.; Disney, M.D. “A general fragment-based approach to identify and optimize bioactive ligands targeting RNA” Proc Natl Acad Sci, 2020, 117, 33197
Joeh, E.; O'Leary, T.; Li, W; Hawkins, R.; Hung, J.; Parker, C.G.; Huang, M.L. “Mapping glycan-mediated galectin-3 interactions by live cell proximity labeling” Proc Natl Acad Sci, 2020, 117, 27329.
bioRxiv preprint, 2020, doi.org/10.1101/2020.05.09.058586
Parker, C.G.*; Pratt, M.R.* “Click Chemistry in Proteomic Investigations” Cell, 2020, 180, 605.
Wang, W.W.; Gallo, L.; Jadhav, A.; Hawkins, R.; Parker, C.G. “The Druggability of Solute Carriers” Journal of Medicinal Chemistry, 2020, 63, 3834.
2019
Galmozzi, A.; Kok, B.P.; Kim, A.S.; Montenegro-Burke, J.R.; Lee, J.Y.; Spreafico, R.; Mosure, S.; Albert, V.; Cintron-Colon, R.; Godio, C.; Webb, W.R.; Conti, B.; Solt, L.A.; Kojetin, D.; Parker, C.G.; Peluso, J.J.; Pru, J.K.; Siuzdak, G.; Cravatt, B.F.; Saez, E. “PGRMC2 is an Intracellular Heme Chaperone Critical for Adipocyte Function” Nature, 2019, 575, 138.
Wang, Y.; Dix, M.M.; Bianco, G.; Remsberg, J.R.; Lee, H.Y.; Kalocsay, M.; Gygi, S.P.; Forli, S.; Vite, G.; Lawrence, R.M.; Parker, C.G.*; Cravatt, B.F.* “Expedited Mapping of the Ligandable Proteome Using Fully Functionalized Enantiomeric Probe Pairs” Nature Chemistry, 2019, 11, 1113.
ChemRxiv pre-print (2019-02-25): doi.org/10.26434/chemrxiv.7764638.v1
highlighted online in Science Translational Medicine: In the Pipeline
GRADUATE & POSTDOCTORAL
Parker, C.G.*; Cravatt, B.F.* “Chemistry Takes Center Stage for Identifying Cancer Targetability” Cell, 2018, 173, 815.
Galmozzi, A.#; Parker, C.G.#, Kok, B. P.; Cravatt, B.F.; Saez, E. “Discovery of Modulators of Adipocyte Physiology Using Fully Functionalized Fragments” Methods Mol Biol, 2018, 1787, 115.
McEnaney, P.J.*; Parker, C.G.*; Zhang, A.X.* “Antibody-Recruiting Small Molecules: Synthetic Constructs as Immunotherapeutics,” Annu Rep Med Chem, 2018, 50, 481.
Parker, C. G.*; Kuttruf, C. A.; Galmozzi, A.; Jorgensen, L.; Chein-Hung, Y.; Hermanson, D.H.; Wang, Y.; Perez, M.E.; McKerrall, S.J.; Joslyn, C. J; Duenstl, G.; Felding, J.; Saez, E.; Baran, P.S.*; Cravatt, B.F*. “Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs” ACS Central Science, 2017, 3, 1276.
Schonhoft, J.D.#; Monteiro, C.#; Plate, L.; Eisele, Y.S.; Kelly, J.; Boland, D.; Parker, C.G.; Cravatt, B.F.; Berk, J.; Sekijima, Y.; Maurer, M.; Novais, M.; Coelho, T.; Powers, E.T.; Kelly, J.W. “Peptide Probes Detect Misfolded Transthyretin Oligomers in the Plasma of Early Stage Hereditary Amyloidosis Patients” Science Translational Medicine, 2017, 9, eaam7621.
Parker, C. G.*#; Galmozzi, A.#; Wang, Y.; Correia, B. E.; Sasaki, K.; Joslyn, C. J.; Kim, A. S.; Cavallaro, C. L.; Lawrence, M.; Johnson, S. R.; Saez, E.*; Cravatt, B. F.* “Ligand and target discovery by fragment-based screening in human cells” Cell, 2017, 168, 527-541.
Featured in News and Analysis in Nature Reviews Drug Discovery, 2017, 16, 225; as a Research Highlight in Nature Protocols, 2017, 225, 52; recommended on F1000prime as being of special significance; highlighted online in Science Translational Medicine: In the Pipeline (3/2/2017) and in Drug Discovery News; TSRI Top 10 Scientific Breakthroughs of 2017.
Parker, C.G.; Dahlgren, M.K.; Li, D.T.; Jawanda, N.; Shoda, T.; Spasov, K.A.; Domaoal, R.A.; Sutton, R.; Anderson, K.S.; Jorgensen, W.L.; Spiegel, D.A. ”Illuminating gp120–Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules” Chemical Science, 2014, 5, 2311-2317.
Jakobsche, C.E.#; Parker, C.G.# Tao, R.N.; Kolesnikova, M.D.; Spiegel, D.A. “Exploring Binding and Effector Functions of Natural Human Antibodies Using Synthetic Immunomodulators” ACS Chemical Biology, 2012, 7, 1139-1151.
McEnaney, P. J.#; Parker, C.G.#; Zhang, A.X.# Spiegel, D.A. “Antibody-Recruiting Molecules: An Emerging Paradigm for Engaging Immune Function in Treating Human Disease” ACS Chemical Biology, 2012, 7, 1139-1151.
Parker, C.G.; Domaoal, R.A.; Anderson, K.S.; Spiegel, D.A. “An Antibody-Recruiting Small Molecule That Targets HIV gp120” J Am Chem Soc, 2009, 131, 16392-16394.
This work was also featured as a spotlight in ACS Chemical Biology, 2009, 4, 975, and was highlighted online by Drug Discovery News, Popular Science, and as ACS Noteworthy Chemistry
